House takes on a case of a patient with two different personalities as a result of having the left and right part of the brain operating independently.

While House tries to cope with his insomnia, he takes on the case of a ballerina whose skin begins to fall off after treatment following the collapse of her lungs during a performance.

A deaf 14-year old wrestler suffers from hearing problems during a match, but his mother refuses to okay cochlear implants. Meanwhile, House’s insomnia proves a curse… and a blessing.

Cameron and Chase are going on vacation when they meet an enviromentalist who collapses in the middle of a protest. They postpone their vacation and ask House to take on the case.

The team deals with an older woman who has been tending to her dying husband but is stricken down with an unknown disease that threatens to kill her before her husband.

House is injured in a motorcycle accident in New York and finds himself in bed next to a patient suffering from complete paralysis. As House transfers the patient to Princeton to determine what’s wrong with him, Wilson tries to find out why House was in New York.

A nursing-home worker (Judy Greer) is alarmed when the home’s cat curls up next to her. It seems that this cat cuddles up only to people who are going to die soon. Meanwhile, a financially strapped Taub reconnects with an entrepreneurial friend from high school.

House and the team take on the case of Nick, a book editor who loses his inhibitions. The team realizes Nick has frontal lobe inhibition, which causes him to speak his mind having no control over what he says and making him just like House. Meanwhile, House suspects Wilson and Taub are keeping something from him.

A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy’s and Wilson’s suspicions that something is terribly wrong.

When a priest who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep, he is admitted to the ER. House takes on the case as a distraction for the team while he confronts Foreman and Thirteen about their relationship. The team soon learns the priest had been involved in a molestation scandal that caused him to lose his faith. However, just as they are about to dismiss his case, the patient�s condition takes a drastic turn for the worse, and House grapples with his past and his beliefs.